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炎性体(inflammasome)是细胞内的一类多蛋白复合物,在炎性反应中发挥着至关重要的作用。炎性体包括半胱天冬酶-1(caspase 1)、PYCARD和NALP,有时也包括半胱天冬酶-5(caspase 5,也被称作半胱天冬酶-11或ICH-3)。它是在骨髓细胞(myeloid cell)中产生的,也是先天性免疫系统的一个组分。炎性体的确切组成依赖于启动炎性体组装的激活物,如双链RNA和
The inflammasome, a type of polyprotein complex in cells, plays a crucial role in the inflammatory response. Inflammasomes include caspase 1, PYCARD, and NALP, and sometimes also caspase 5 (also known as caspase-11 or ICH-3) . It is produced in myeloid cells and is a component of the innate immune system. The exact composition of the inflammasome depends on the activators that initiate the assembly of the inflammasome, such as double stranded RNA and