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目的探讨CYP11B2基因-344C/T多态性与原发性高血压及其靶器官损伤的关系。方法检测对照组、原发性高血压无并发症组、高血压合并脑梗死组和高血压左室肥厚组患者的CYP11B2基因型频率,统计学分析比较其差异。结果高血压组和对照组的C等位基因频率分别为0.28、0.19,统计学分析提示高血压组的C等位基因频率显著高于对照组(P<0.01);高血压合并脑梗死组与无并发症组的C等位基因频率分别为0.33、0.27,两者之间无显著差别(P>0.05);高血压合并脑梗死组与无并发症组的T等位基因频率分别为0.67、0.73,两者之间无显著差别(P>0.05);高血压左室肥厚组和无并发症组的T等位基因频率分别为0.78、0.73,高血压左室肥厚组显著高于无并发症组(P<0.005)。结论 CYP11B2基因C等位基因可能是原发性高血压的一个遗传标志。高血压合并脑梗死的发生与CYP11B2基因多态性无关,高血压左室肥厚的发生与CYP11B2基因T等位基因有关。
Objective To investigate the association of CYP11B2 gene -344C / T polymorphism with essential hypertension and its target organ damage. Methods The frequencies of CYP11B2 genotypes in control group, non-complication of essential hypertension group, hypertensive cerebral infarction group and hypertensive left ventricular hypertrophy group were detected. The differences were statistically analyzed. Results The frequencies of C allele in hypertension group and control group were 0.28 and 0.19, respectively. Statistical analysis showed that the frequency of C allele in hypertension group was significantly higher than that in control group (P <0.01). Hypertension with cerebral infarction group The frequency of C allele in non-complication group was 0.33 and 0.27, respectively (P> 0.05). The frequencies of T allele in hypertension group and non-complication group were 0.67, 0.73, there was no significant difference between them (P> 0.05). The frequencies of T allele in hypertensive left ventricular hypertrophy group and uncomplicated group were 0.78,0.73, hypertensive left ventricular hypertrophy group was significantly higher than non-complication Group (P <0.005). Conclusion CYP11B2 gene C allele may be a genetic marker of essential hypertension. The incidence of hypertension complicated with cerebral infarction has nothing to do with the polymorphism of CYP11B2 gene. The occurrence of hypertensive left ventricular hypertrophy is related to the T allele of CYP11B2 gene.