目的:分析少白细胞悬浮红细胞和普通悬浮红细胞输注对再生障碍性贫血患者红细胞免疫功能及凝血的影响。方法:选取2017年12月至2019年01月连云港市第一人民医院需要输血的再生障碍性贫血患者114例，随机分为少白细胞悬浮红细胞组(简称少白组，57例)和普通悬浮红细胞组(简称普通组，57例)。两组患者均予以环孢素和康力龙治疗，并输注血浆、血小板等血液制剂。在此基础上，少白组均加以少白细胞悬浮红细胞输注，普通组均加以普通悬浮红细胞输注。对比两组患者治疗前后的细胞免疫功能[红细胞C3b受体花环率(red blood cell-Cn 3b receptor garland rate，RBC-Cn 3bRR)、红细胞免疫复合物(red blood cell-circulation immune complex，RBC-CIC)以及红细胞超氧化物歧化酶(red blood cell-superoxide dismutase，RBC-SOD)]和凝血指标[凝血酶原时间(prothrombin time，PT)、活化部分凝血酶原时间(activated partial thromboplastin time，APTT)、纤维蛋白原(fibrinogen，FIB)和凝血酶时间(thrombin time，TT)]，并对比两组输血反应发生率。n 结果:治疗前少白组和普通组红细胞免疫功能与凝血指标差异均无统计学意义(n P>0.05)；治疗后两组患者RBC-Cn 3bRR、RBC-CIC和RBC-SOD水平均较治疗前明显升高[少白组：(18.36±2.44)%比(13.67±1.98)%，(14.36±2.26)%比(8.38±2.11)%，(70.34±12.68)μg/mg比(50.77±7.69)μg/mg，n t值分别为11.268、14.602和9.963，n P值均<0.05；普通组：(15.72±2.67)%比(13.39±2.14)%，(11.25±2.38)%比(8.42±2.04)%，(65.95±9.42)μg/mg比(51.08±8.61)μg/mg，n t值分别为5.141、6.816和8.797，n P值均<0.05]，差异具有统计学意义。另外，少白组RBC-Cn 3bRR, RBC-CIC，RBC-SOD和FIB均高于普通组[(18.36±2.44)%比(15.72±2.67)%，(14.36±2.26)%比(11.25±2.38)%，(70.34±12.68)μg/mg比(65.95±9.42)μg/mg，(3.48±0.37)g/L比(2.83±0.41)g/L，n t值分别为5.511、7.154、2.098和8.886，n P值均<0.05]，差异具有统计学意义。治疗后两组PT、APTT、TT均较治疗前明显缩短[少白组：(14.31±2.49)s比(18.25±2.36)s，(35.64±5.15)s比(42.39±4.16)s，(16.65±2.34)s比(19.46±2.66)s，n t值分别为8.671、7.698和5.988，n P值均<0.05；普通组：(16.86±2.57)s比(18.67±2.62)s，(38.61±5.34)s比(41.54±4.31)s，(17.97±2.15)s比(19.35±2.96)s，n t值分别为3.723、3.224和2.848，n P值均<0.05]，且治疗后少白组PT、APTT、TT均短于普通组[(14.31±2.49)s比(16.86±2.57)s，(35.64±5.15)s比(38.61±5.34)s，(16.65±2.34)s比(17.97±2.15)s，n t值分别为3.155、3.022和3.136，n P值均<0.05]；少白组输血反应发生率低于普通组[(1.75%比7.02%)，n χ2＝2.837，n P0.05). After treatment, the levels of RBC-Cn 3bRR, RBC-CIC and RBC-SOD in the two groups were significantly higher than those before treatment[oligoleukocytes group: (18.36±2.44)% vs(13.67±1.98)%, (14.36±2.26)% vs(8.38±2.11)%, (70.34±12.68) μg/mg vs(50.77±7.69) μg/mg, n t values were 11.268, 14.602 and 9.963 respectively, all n P values<0.05; normal group: (15.72±2.67)% vs(13.39±2.14) %, (11.25±2.38) % vs(8.42±2.04)%, (65.95±9.42)μg/mg vs(51.08±8.61) μg/mg,n t values were 5.141, 6.816 and 8.797 respectively, all n P values <0.05]. RBC-C n 3bRR, RBC-CIC, RBC-SOD and FIB in the oligoleukocytes group were also higher than those in the normal group [(18.36±2.44)% vs(15.72±2.67)%, (14.36±2.26)% vs(11.25±2.38)%, (70.34±12.68)μg/mg vs(65.95±9.42)μg/mg, (3.48±0.37)g/L vs(2.83±0.41)g/L,n t values were 5.511, 7.154, 2.098 and 8.886 respectively, all n P values <0.05]. After treatment, the PT, APTT and TT in the two groups were significantly shorten than before treatment [oligoleukocytes group: (14.31±2.49)s vs(18.25±2.36)s, (35.64±5.15)s vs(42.39±4.16)s, (16.65±2.34)s vs(19.46±2.66)s, n t values were 8.671, 7.698 and 5.988 respectively, all n P values<0.05; normal group: (16.86±2.57)s vs(18.67±2.62)s, (38.61±5.34)s vs(41.54±4.31)s, (17.97±2.15)s vs(19.35±2.96)s,n t values were 3.723, 3.224 and 2.848 respectively, all n P values <0.05]. The PT, APTT and TT in the oligoleukocytes group were also shorter than those in the normal group [(14.31±2.49)s vs(16.86±2.57)s, (35.64±5.15)s vs(38.61±5.34)s, (16.65±2.34)s vs(17.97±2.15)s, n t values were 3.155, 3.022 and 3.136 respectively, all n P values <0.05]. The incidence of transfusion reaction in the oligoleukocytes group was lower than that in the normal group [(1.75% vs 7.02%), n χ2=2.837, n P<0.05 ].n Conclusion:Compared with the normal suspension red blood cell infusion, oligoleukocytes suspended erythrocytes infusion can better regulate the immune function, improve the coagulation function, and the incidence of transfusion reaction is lower.