目的:分析持续性血液净化治疗严重脓毒症的有效性。方法:选取2019年4月至2020年7月我院收治的78例严重脓毒症患者，随机分为两组。对照组患者采取常规治疗方案，观察组患者在对照组的基础上加入持续性血液净化治疗。比较两组患者治疗有效率、重症监护室(ICU)住院时间、治疗前与治疗72 h后血清炎症因子水平差异。结果:观察组患者的治疗有效率明显高于对照组患者(n P<0.05)，ICU住院时间明显短于对照组患者(n P0.05)；治疗后观察组患者IL-6、TNF-α、CRP等指标均明显低于对照组患者(n P< 0.05)。n 结论:应用持续性血液净化治疗严重脓毒症患者有助于提高患者的治疗效果，降低血清炎症因子水平，缩短患者ICU住院时间，值得推广使用。“,”Objective:To analyze the effectiveness of continuous blood purification in the treatment of severe sepsis.Methods:A total of 78 patients with severe sepsis admitted to the hospital from April 2019 to July 2020 were selected and randomly divided into the control group and the observation group. The patients in the control group received the conventional treatment, and the observation group received the continuous blood purification on the basis of the conventional treatment. The differences in effective treatment rate and length of intensive care unit (ICU) stay between the two groups of patients were compared, and the difference in serum inflammatory factor indexes between the two groups before treatment and 72 hours after treatment was compared.Results:The effective rate of treatment in the observation group was significantly higher than that in the control group (n P<0.05), and the length of stay in the ICU was significantly lower than that in the control group (n P0.05), and the level of IL-6, TNF-α and CRP in the observation group were significantly lower than those in the control group (n P<0.05).n Conclusion:The application of continuous blood purification in the treatment of patients with severe sepsis can improve the clinical efficacy of the patients, reduce the level of serum inflammatory factors, and thus shorten the patient’s ICU stay.