精子膜表面抗精子抗体与精液参数的关系

来源 :中国男科学杂志 | 被引量 : 0次 | 上传用户:kbens
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的 探讨精子膜表面AsAb导致男性不育的机制。方法 对102例不孕夫妇的丈夫精液进行混合球蛋白反应试验(MAR),其中48例同时进行了血清AsAb的检测。结果 48例同时进行MAR和ELISA的不育男性,精液MAR阳性率为14.6%(7/48);血清ELISA阳性率为50%(24/48)。两种方法的阳性率有非常显著性差异(P<0.001)。102例进行MAR检测的不育男性中,随着精液量、密度、存活率、活动力、畸形率的变化,精子膜表面AsAb的阳性率均无显著性差异(P>0.05)。根据精子膜表面AsAb阳性与否分成两组组间的病人年龄、精液量、密度、存活率、活动力、畸形率均无显著性差异(P>0.05)。结论 血清ELISA阳性率过高,不宜用于不育男性免疫因素的检测;精液精子膜表面AsAb并不影响精液分析的各项参数。因此,精液各项参数的分析对于男性免疫因素不育的筛查没有太大的意义。 Objective To investigate the mechanism of male infertility caused by AsAb on the surface of sperm membrane. Methods A total of 102 infertile couples were tested for mixed globulin response (MAR), of which 48 were tested for serum AsAb at the same time. Results In 48 infertile men with MAR and ELISA, the positive rate of semen MAR was 14.6% (7/48). The positive rate of serum ELISA was 50% (24/48). There was a very significant difference between the two methods (P <0.001). There was no significant difference in the positive rate of AsAb on the sperm membrane between 102 males with MAR (P> 0.05), with the changes of sperm volume, density, survival rate, motility and deformity. There was no significant difference in age, semen volume, density, survival rate, activity, and deformity between the two groups according to AsAb positive or not on the surface of sperm membrane (P> 0.05). Conclusion Serum ELISA positive rate is too high, not suitable for the detection of infertile male immune factors; sperm membrane surface AsAb does not affect the semen analysis of the parameters. Therefore, the analysis of various parameters of semen for infertility screening of male immune factors is not much significance.
其他文献
我们对比观察了氧氟沙星注射液和片剂对呼吸道和尿路感染的疗效,从而对氧氟沙星注射液进行临床评价。
通过给大鼠腹腔注射HgCl2和Acivicin,观察了Acivicin对γ-GTP活力及HgCl2代谢的影响。结果表明,按25mmol/kg注射Acivicin后1h,肾γ-GTP活力下降至正常的36%左右,50μmol/kg组下降更加显著,8h后恢复正常。给Acivicin组肝汞、肾汞含量均显著下降,尿汞含量显著增加。提示Acivicin通过有效地抑制肾γ-GTP活力,影响HgCl2在体内的代谢