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目的:建立益髓生血颗粒的质量标准。方法:采用TLC对处方中的山茱萸,制何首乌,灸黄芪,当归,补骨脂和砂仁进行定性鉴别;用HPLC测定益髓生血颗粒中马钱苷的含量。结果:薄层图谱斑点清晰,阴性对照无干扰;马钱苷在0.13～0.78μg呈良好的线性关系,平均回收率为101.3%,RSD为2.02%。结论:建立的方法简便,准确,重复性好,精密度高,可用于益髓生血颗粒的质量控制。
Objective: To establish the quality standard of Yisheng Shengxue Granule. Methods: The prescriptions of Cornus officinalis, Radix et Rhizoma Polygoni multiflori, Radix Astragali, Radix Angelicae Sinensis, Radix Angelicae Sinensis and Amomum villosum were identified qualitatively by TLC. The content of Loganin in Yisui Shengxue Granules was determined by HPLC. Results: The spots of the TLC showed clear spots without any interference with the negative control. The loganin was linear in the range of 0.13 ~ 0.78μg with an average recovery of 101.3% and a RSD of 2.02%. Conclusion: The established method is simple, accurate, reproducible, high precision and can be used for the quality control of Yisheng Shengxue Granule.