【目的】探讨曲美他嗪预处理一周对离体鼠心缺血再灌注损伤的影响。【方法】 30只 15周龄的SD大鼠随机分成 3组 ,分别以曲美他嗪 2 0mg/(kg·d)、40mg/(kg·d)及蒸馏水每天灌胃 1次 ,7d后用Langendroff离体心脏灌注法 ,缺血 45min后复灌 ,测量全程左室内压和心电图的变化。【结果】曲美他嗪 40mg/(kg·d)、2 0mg/(kg·d)组的复跳时间分别为 ( 2 14± 0 5 4)、( 5 2 6± 1 0 6 )min ,均较对照组的 ( 10 32± 1 89)min为短 (P均 <0 0 0 1)。复灌后与缺血前的最大左室压力的比值及最大左室压力变化速率的比值在曲美他嗪各实验组均明显大于对照组 (P均 <0 0 0 1)。另外 ,曲美他嗪各组再灌注心律失常的总发生率 ,尤其是室速的发生率均明显小于对照组 (P均 <0 0 1)。【结论】曲美他嗪预处理对离体缺血再灌注鼠心有保护作用。 【Objective】 To investigate the effect of trimetazidine preconditioning on isolated rat heart ischemia-reperfusion injury in one week. 【Methods】 Thirty 15-week-old SD rats were randomly divided into three groups. The rats were treated with trimetazidine 20 mg / (kg · d), 40 mg / (kg · d) and distilled water once daily for 7 days, respectively. Langendroff perfusion in vitro, reperfusion after 45min of ischemia, measurement of left ventricular pressure and ECG changes. 【Results】 The mean recovery times of trimetazidine 40 mg / (kg · d) and 20 mg / (kg · d) were (2 14 ± 0 54) and (526 ± 1 0 6) min, (10 32 ± 1 89 min) in the control group was shorter than that in the control group (all P 0 01). The ratio of maximal left ventricular pressure and maximum rate of left ventricular pressure change after reperfusion was significantly higher in trimetazidine groups than in control group (all P <0.01). In addition, the overall incidence of reperfusion arrhythmia, especially the incidence of ventricular tachyarrhythmias in trimetazidine groups was significantly lower than that of the control group (all P <0.01). 【Conclusion】 Trimetazidine pretreatment has a protective effect on isolated rat hearts from ischemia / reperfusion.