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目的:探讨血清胱抑素C与β2微球蛋白(β2-MG)的水平在窒息新生儿早期肾功能损伤诊断中的价值。方法:选取足月窒息新生儿重度组50例和轻度组40例,足月正常新生儿50例做对照组,对3组新生儿血清胱抑素C和β2-MG的水平进行检测并与血清尿素氮肌酐水平进行比对分析。结果:血清尿素氮和肌酐水平仅重度组明显高于正常对照组,差异具有统计学意义(P<0.05);轻度窒息组的血清尿素和肌酐与正常对照组比较,差异无统计学意义(P>0.05),血清胱抑素C与β2-MG的水平重度组与轻度组明显高于正常新生儿对照组,差异具有统计学意义(P<0.05),并且新生儿窒息程度与血清胱抑素C与β2-MG的水平呈正相关。结论:血清胱抑素C与β2-MG水平可以作为窒息新生儿肾功能早期损伤诊断的敏感指标。
Objective: To investigate the value of serum levels of cystatin C and β2-microglobulin (β2-MG) in the diagnosis of early renal damage in neonatal asphyxia. Methods: 50 cases of full-term asphyxia neonatorum severe group and 40 mild cases, 50 full-term normal newborns as control group, the three groups of newborns serum cystatin C and β2-MG levels were detected and Serum urea nitrogen creatinine levels were compared analysis. Results: Serum urea nitrogen and creatinine levels were significantly higher in the severe group than in the normal control group (P <0.05). There was no significant difference in serum urea and creatinine between the mild asphyxia group and the normal control group P> 0.05). The levels of serum cystatin C and β2-MG in severe group and mild group were significantly higher than those in normal neonates (P <0.05), and the degree of neonatal asphyxia was similar to that in serum There was a positive correlation between the levels of somatostatin C and β2-MG. Conclusion: Serum levels of cystatin C and β2-MG can be used as sensitive indicators for diagnosis of early renal damage in neonatal asphyxia.