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目的观察缺血性脑血管病患者相关血管开通前后致炎细胞因子肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和抗炎细胞因子白细胞介素-10(IL-10)的动态变化。方法采用酶联免疫吸附法测定30例健康人(健康对照组)和30例缺血性脑血管病患者急诊介入治疗术前即刻、术后12、24h,血浆TNF-α、IL-6、IL-10的变化,比较致炎细胞因子TNF-α、IL-6和抗炎细胞因子IL-10的动态变化。结果再灌注前急诊介入组患者TNF-α、IL-6显著高于健康对照组(P<0.05),血浆IL-10略高于健康对照组,但差异无统计学意义(P>0.05);再灌注后12、24h急诊介入组患者血浆TNF-α、IL-6、IL-10均较术前显著增高(P<0.01,P<0.05)。急诊介入组患者再灌注治疗后12h抗炎细胞因子IL-10的升高幅度显著低于致炎细胞因子TNF-α、IL-6的升幅(P<0.01)。结论缺血性脑血管病再灌注后致炎细胞因子较抗炎细胞因子增高更显著。
Objective To observe the changes of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and anti-inflammatory cytokines interleukin-10 -10) dynamic changes. Methods Serum levels of TNF-α, IL-6 and IL-6 were measured by enzyme-linked immunosorbent assay immediately after emergency intervention in 30 healthy people (healthy control group) and 30 patients with ischemic cerebrovascular disease -10 changes in the inflammatory cytokines TNF-α, IL-6 and anti-inflammatory cytokines IL-10 dynamic changes. Results The levels of TNF-α and IL-6 in emergency intervention group before reperfusion were significantly higher than those in healthy control group (P <0.05), and plasma IL-10 level was slightly higher than that in healthy control group (P> 0.05). The level of plasma TNF-α, IL-6 and IL-10 in emergency intervention group at 12 and 24 hours after reperfusion were significantly higher than those before operation (P <0.01, P <0.05). The increase of anti-inflammatory cytokines IL-10 at 12 h after reperfusion in emergency intervention group was significantly lower than that of inflammatory cytokines TNF-α and IL-6 (P <0.01). Conclusion The reperfusion of ischemic cerebrovascular disease is more significant than that of anti-inflammatory cytokines.