目的：研究人胆汁中罗红霉素的代谢转化产物。方法：采用高效液相色谱离子阱质谱法，对患者ｐｏ罗红霉素后的胆汁样品进行了分析。结果：发现了１３个代谢产物，分别为罗红霉素的（９Ｚ）异构体及其（９Ｅ），（９Ｚ）Ｎ去甲基和Ｎ双去甲基衍生物和（９Ｅ）及（９Ｚ）脱克拉定糖衍生物，（９Ｅ）和（９Ｚ）红霉素肟及其（９Ｅ）和（９Ｚ）Ｎ去甲基及Ｎ双去甲基衍生物，其中９种为新发现的代谢物。结论：罗红霉素及其代谢物均可在体内发生几何异构化 Objective: To study the metabolic conversion products of roxithromycin in human bile. METHODS: Bile samples from patients po po roxithromycin were analyzed by high performance liquid chromatography-ion trap mass spectrometry. RESULTS: Thirteen metabolites were found, which were (9Z) isomer of roxithromycin, (9E) , (9Z) Ndemethyl and Ndimethylsilyl derivatives and 9E)  and (9Z)  descladinose derivatives, (9E)  and (9Z)  erythromycin oxime and its (9E)  and (9Z)  N  desmethyl and Ndistribution Among them, nine were newly discovered metabolites. Conclusion: Roxithromycin and its metabolites can all undergo geometric isomerization in vivo