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目的探讨慢性乙型肝炎患者聚乙二醇干扰素疗效与血清铁蛋白变化的关系。方法观察50例聚乙二醇干扰素治疗的乙型肝炎患者临床疗效,同时测其血清铁蛋白水平。结果血清铁蛋白的增高与肝脏病变的严重程度呈正比。在聚乙二醇干扰素治疗的50例患者中,血清铁蛋白水平<400ng/ml者疗效明显优于400ng/ml以上者(P<0.005),提示血清铁蛋白水平增高使患者对聚乙二醇干扰素的反应降低。在有治疗反应的25例患者中,持续应答者与暂时应答者血清铁蛋白均值差异有显著意义(P<0.005)。结论血清铁蛋白水平较高可能降低对干扰素治疗的反应性且使疗效不稳定。
Objective To investigate the relationship between pegylated interferon (IFN) and serum ferritin in patients with chronic hepatitis B Methods 50 cases of pegylated interferon treatment of hepatitis B patients with clinical efficacy, meanwhile, serum ferritin levels were measured. Results Serum ferritin increased in proportion to the severity of liver disease. Among the 50 patients treated with pegylated interferon, the serum ferritin level of <400 ng / ml was significantly better than that of 400 ng / ml (P <0.005), suggesting that elevated serum ferritin levels led to a Alcohol interferon response decreased. Among the 25 patients who responded to the therapy, there was a significant difference in mean serum ferritin between continuing responders and transient responders (P <0.005). Conclusions A higher serum ferritin level may reduce the response to interferon therapy and render the efficacy unstable.