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成熟的不再增殖的肺组织,蛋白成分平均每4～5d就会再次合成。如此高的生物合成活性,说明肺存在着一套很好的平衡控制系统,它能保持正常组织结构和功能的稳定。保持和调控肺细胞功能及分子合成的物质就是细胞因子(cytokines),也被称为肽生长因子或生物反应调节物。当肺正常稳定的解剖和生理关系被干扰时,会立刻导致细胞和细胞间的级联讯号事件,这个事件是由肺释放的细胞因子凋控的。笔者简要综述肺细胞因子的种类、生物活性特点及与放射性肺损伤的关系和放射性肺损伤防治策略的研究。
Mature lung tissue is no longer proliferating, the average protein composition every 4 ~ 5d will be re-synthesized. Such high biosynthetic activity indicates that there is a well-established balance control system in the lung that maintains normal tissue structure and functional stability. Substances that maintain and regulate lung cell function and molecular synthesis are cytokines, also known as peptide growth factors or biological response regulators. When the normal, stable anatomy and physiology of the lungs interfere, they immediately cause a cascade of signaling events between cells and cells, a event that is witnessed by the release of cytokines by the lungs. The author briefly reviewed the types of lung cytokines, biological characteristics and the relationship with radiation-induced lung injury and radiation-induced lung injury prevention and control strategies.