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近年来对乙型肝炎的治疗有很大的进展,具体表现为新的有效抗病毒药物不断涌现,而且各具特色,为彻底清除肝内乙型肝炎病毒(HBV)提供了一些手段。此外由于对HBV引起慢性持续性感染机制逐步的深入了解,也为今后探索新的治疗途径找到新的切入口。但目前也遇到新的挑战。1.如何消灭病毒持续感染?治疗乙型肝炎的目的是消除肝内病变,防止发展为肝硬化及肝癌。目前采用核酸类似物治疗乙型肝炎,疗程不当停药后易引起病情反跳,病毒重新活跃复制,主要和肝内HBV
In recent years, great progress has been made in the treatment of hepatitis B, which is manifested in the continuous emergence of new and effective antiviral drugs and their distinctive features, thus providing some means for thoroughly eliminating hepatitis B virus in the liver. In addition, due to the gradual and thorough understanding of the mechanism of chronic persistent infection caused by HBV, it also finds new entrances for exploring new therapeutic approaches in the future. However, new challenges are also encountered. 1. How to eliminate persistent virus infection? Treatment of hepatitis B aims to eliminate intrahepatic lesions and prevent the development of cirrhosis and liver cancer. At present, the use of nucleic acid analogues for the treatment of hepatitis B, improper treatment is easy to cause disease rebound after withdrawal, the virus re-active replication, mainly in liver and HBV