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目的:评价肾移植后患者尿中可溶性细胞间粘附分子-1(sICAM-1)浓度变化的临床意义。方法:动态检测20例肾移植患者术后2个月内尿中sICAM-1浓度的变化。结果:急性排斥反应(AR)时,sICAM-1的升高较临床诊断提早数天,并且显著高于环孢素A肾中毒组;对甲基氢化泼尼松敏感的排斥反应,抗排斥治疗数天后sICAM-1下降到排斥前水平。结论:肾移植术后动态监测受者尿中sICAM-1浓度有助于AR的早期诊断、鉴别诊断、及时治疗和甲基氢化泼尼松抗排斥的疗效评价。
Objective: To evaluate the clinical significance of urinary soluble intercellular adhesion molecule-1 (sICAM-1) in renal transplant recipients. Methods: The changes of urinary sICAM-1 concentration in 20 patients with renal transplantation were detected dynamically within 2 months after operation. Results: In acute rejection (AR), the increase of sICAM-1 was earlier than that of clinical diagnosis, and was significantly higher than that of cyclosporine A nephrotoxicity group. Methylprednisolone-induced rejection and anti-rejection therapy After a few days sICAM-1 dropped to the pre-exclusion level. CONCLUSIONS: The dynamic monitoring of sICAM-1 concentration in urine of recipients after renal transplantation is helpful for the early diagnosis, differential diagnosis, timely treatment and anti-rejection of methylprednisolone.