目的　探索心理社会应激与综合健康效应关系的研究方法 ,了解心理社会因素对人群综合健康状况的影响。方法　随机整群抽取四川某厂 116 0名职工作为研究对象 ,随访其社会经济人口学特征、生活事件、社会支持、心身症状、社会功能缺陷、现患疾病等 ,以前三者为原因变量 ,后三者经主成分分析所产生的综合健康和躯体、社会、心理三个单维度健康为结局变量 ,对变量进行分类、等级化处理后 ,进行单因素和多因素分析。结果　与社会和心理健康比 ,躯体健康的发病率较高 ,好转率较低 ;各结局变量异常率在社会人口经济学特征上的分布未得出有显著性差异的结果 ;生活事件刺激量、年龄和工龄进入多数回归方程 ,均为正相关因素。结论　躯体健康是该人群的主要健康问题 ;生活事件刺激量较多、年龄较大或工龄较长是健康状况不良改变的危险因素 Objective To explore the relationship between psychosocial stress and general health effects of research methods to understand the impact of psychological and social factors on the comprehensive health status of the population. Methods A total of 116 0 workers from a factory in Sichuan were randomized to study the socio-economic demographic characteristics, life events, social support, psychosomatic symptoms, social dysfunction, current illness, etc. The former three were the causal variables The three groups were analyzed by the principal component analysis of comprehensive health and physical, social and psychological three unidimensional health as the outcome variable, the variables were classified, hierarchical treatment, the single factor and multivariate analysis. Results Compared with the social and psychological health, the incidence of physical health is higher and the rate of improvement is lower. The distribution of the abnormal rate of each outcome variable in the socio-demographic characteristics does not show any significant difference. The stimulation of life events, Age and seniority into the majority of regression equations are positive correlation. Conclusion Somatic health is the main health problem in this population. The more life-events stimulated, the older or longer service life are the risk factors of poor health status