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目的 探讨舍格林综合征患者唇腺组织中的淋巴细胞过度浸润及激活与白细胞介素 -1(IL -1β)和肿瘤坏死因子 -α(TNF -α)的关系。方法 通过HE染色观察淋巴细胞的浸润 ,采用免疫组织化学法检测IL -1β和TNF -α蛋白的表达 ,运用图象分析技术对结果进行定量分析。结果 唇腺组织中的IL -1β和TNF -α蛋白表达与淋巴细胞浸润密切相关 ;淋巴细胞浸润密集的组织 ,炎症浸润广泛 ,导管上皮增生与腺泡破坏显著。结论 与IL-1β和TNF -α等细胞因子相关的淋巴细胞浸润与激活促进了舍格林综合征的发展
Objective To investigate the relationship between interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) in lymph gland tissues of Sjogren’s Syndrome. Methods The infiltration of lymphocytes was observed by HE staining. The expression of IL - 1β and TNF - α protein was detected by immunohistochemistry. The results were analyzed quantitatively by image analysis technique. Results The expressions of IL-1β and TNF-α in labial gland tissues were closely related to the infiltration of lymphocytes. The tissues infiltrated by lymphocytes were infiltrated extensively with extensive infiltration and hyperplasia of ductal epithelium and acinus. Conclusion Lymphocyte infiltration and activation associated with cytokines such as IL-1β and TNF-α promote the development of schönling syndrome