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目的评价人类白细胞抗原HLA-B27在强直性脊柱炎(AS)临床诊断中的作用。方法采用磁珠酶免疫分析法对259名AS患者进行检测,另设150例健康人为正常对照组。结果 259名AS患者中HLA-B27抗原阳性238例,阳性率91.9%,抗原阳性组中,发病年龄在40岁以内共224例,占阳性组的94.1%,男性阳性率明显高于女性,而特异性和阳性预测值在不同性别间无显著差异。结论 HLA-B27表现出很高的病态识别度。不同性别患者之间的差异提示AS可能与体内激素水平有一定的关系。HLA-B27抗原检测对AS的临床诊治和科学研究都有一定价值。
Objective To evaluate the role of human leukocyte antigen HLA-B27 in the clinical diagnosis of ankylosing spondylitis (AS). Methods 259 patients with AS were tested by magnetic beads immunoassay, and another 150 healthy controls were selected as normal control group. Results There were 238 HLA-B27 positive cases in 259 AS patients, the positive rate was 91.9%. In antigen-positive group, the onset age was within 40 years old, a total of 224 cases, accounting for 94.1% of the positive group, the male positive rate was significantly higher than that of women Specificity and positive predictive values were not significantly different between genders. Conclusion HLA-B27 showed high pathological identification. The differences between patients of different genders suggest that AS may have a certain relationship with hormone levels in the body. HLA-B27 antigen test for the clinical diagnosis and treatment of AS and scientific research have some value.