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目的探讨早期应用药物治疗慢性呼吸衰竭并发肺性脑病的临床效果。方法选取许昌县人民医院2011年2月至2013年2月收治的86例慢性呼吸衰竭并发肺性脑病患者,随机分为观察组与参考组,每组43例,给予两组患者吸氧、原发病治疗、抗生素治疗、纠正水、电解质及酸碱平衡等常规治疗,观察组在此基础上同时采用纳洛酮治疗,观察两组患者临床治疗效果及血气分析结果。结果观察组治疗总有效率为93%,参考组为76.7%,两组比较差异有统计学意义(P<0.05);两组患者治疗中均未出现严重并发症,差异无统计学意义(P>0.05);两组患者治疗后PaO2、PaCO2均有明显改善,观察组患者改善情况明显优于参考组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上采用纳洛酮治疗慢性呼吸衰竭并发肺性脑病疗效显著,安全性高,值得推广使用。
Objective To investigate the clinical effect of early application of drugs in treating pulmonary respiratory failure complicated by pulmonary encephalopathy. Methods Eighty-six patients with chronic respiratory failure and pulmonary encephalopathy admitted to Xuchang People’s Hospital from February 2011 to February 2013 were randomly divided into observation group and reference group, 43 cases in each group. Patients in both groups were given oxygen, Onset treatment, antibiotic treatment, correction of water, electrolyte and acid-base balance routine treatment, the observation group on the basis of naloxone treatment at the same time, the clinical efficacy and blood gas analysis results of two groups were observed. Results The total effective rate was 93% in the observation group and 76.7% in the reference group, with significant difference between the two groups (P <0.05). No serious complications occurred in the two groups, and the difference was not statistically significant (P > 0.05). PaO2 and PaCO2 were significantly improved in both groups after treatment, and the improvement in observation group was significantly better than that in reference group (P <0.05). Conclusion Naloxone on the basis of conventional treatment of chronic respiratory failure complicated with pulmonary encephalopathy significant effect, high safety, it is worth promoting the use of.