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将43只实验大鼠分成5组:肝损伤组给CCI_4皮下注射;大黄组、赤芍组、栀子组除给CCI_4皮下注射外,分别给以上述各药煎剂灌胃各共7日;对照组皮下注射生理盐水,并以自来水灌胃。结果,三个中药治疗组与肝损伤组相比,除栀子组外,大黄组及赤芍组均使肝损伤区域缩小,肝细胞中脂滴减少,细胞核增大,RNA、核仁增多,糖原恢复,琥珀酸脱氢酶和葡萄糖-6-磷酸酶活性增强,粗面内质网恢复平行排列,滑面内质同增加,线粒体形态结构恢复、数量增加,表明大黄及赤芍对CCI_4所致肝损伤均有修复作用(大黄更佳),其机制可能是通过内质同损伤的阻止,促进蛋白质合成及解毒,恢复了肝功能。
43 experimental rats were divided into 5 groups: the liver injury group was injected subcutaneously with CCI_4; the rhubarb group, the red peony group, and the wolfberry group were given subcutaneous injections of CCI_4, and each of the above-mentioned drug decoctions was intragastrically administered for a total of 7 days; The control group was injected subcutaneously with normal saline and fed with tap water. As a result, compared with the liver injury group, the three Chinese medicine treatment groups except the wolfberry fruit group, the rhubarb group and the red peony group all reduced the hepatic injury area, reduced the lipid droplets in the liver cells, increased the nucleus, increased RNA, nucleolus, Glycogen recovery, succinate dehydrogenase and glucose-6-phosphatase activity were enhanced, the rough endoplasmic reticulum was restored in parallel, the slippery surface endoplasmic reticulum increased, and the mitochondrial morphological structure was restored and the number increased, indicating that Rhubarb and Astragalus membranaceus were CCI_4 Liver damage caused by the repair (Rhubarb better), the mechanism may be through the prevention of endoplasmic damage, promote protein synthesis and detoxification, restore liver function.