丙型肝炎病毒感染常呈慢性化 ,且易使病情进一步发展为肝硬化和肝细胞癌。其基因的多变性使得疫苗研究进展缓慢 ,鉴于NS3蛋白酶在病毒体的成熟和复制中所起的重要作用 ,阐明结构和功能 ,寻找其抑制剂可能对抗病毒治疗有重要意义 Hepatitis C virus infection is often chronic, and easy to make the disease further development of cirrhosis and hepatocellular carcinoma. The variability of the gene makes the progress of vaccine research slow. Given the important role of NS3 protease in the maturation and replication of virosomes, elucidating the structure and function, finding inhibitors of it may be of great importance to anti-viral therapy