应用多聚酶链反应 -限制性片段长度多态性 (PCR- RFL P)技术对 2 12例山东省汉族人 (非糖尿病 80例 ,2型糖尿病 132例 )进行 β3 肾上腺能受体 (β3 AR)基因 Trp6 4 Arg突变分析。结果表明 ,山东汉人β3 AR Trp6 4 Arg等位基因变异频率为 15% ,2型糖尿病组与非糖尿病组β3 AR Trp6 4 Arg基因型和等位基因分布频率无显著差异 (P>0 .0 5)。提示山东省汉族人存在 β3 AR基因变异 ,但这种变异与2型糖尿病无密切关联 The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the β3 adrenergic receptor (β3 AR) gene in 212 Chinese Han patients (80 non-diabetic and 132 type 2 diabetic) Trp6 4 Arg mutation analysis. The results showed that there was no significant difference in the genotype and allele frequencies of β3 AR Trp6 4 Arg between type 2 diabetes and non-diabetic patients (P> 0.05) ). It is suggested that the β3AR gene variation exists in Shandong Han people, but this variation is not closely related to type 2 diabetes