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目的使用实时三维超声心动图技术(RT-3DE)和二维斑点追踪技术(2D-STI)评估系统性红斑狼疮(SLE)所致的肺动脉高压(PAH)对双心室收缩功能的影响。方法将研究对象按有无PAH及严重程度分为无(NPAH)、轻(LPAH)、中(MPAH)及重度PAH(SPAH)组,各为23例,19例,18例,12例。RT-3DE获取双心室射血分数(LVEF/RVEF),通过2D-STI计算左心室前壁(ANT)、室间隔(SEP)、侧壁(LAT)及下壁(INF)心肌纵向应变(LS)平均值(LSA)及圆周应变(CS)平均值(CSA),比较各组间的差异。结果仅SPAH组LVEF值降至正常水平以下;而LS随PAH增加而降低,ANT及SEP的LSA降低明显,而INF及LAT变化较不明显;CS则先增加后降低,SEP、ANT及INF的CSA变化比较明显。结论 SLE所致的PAH对双心室收缩功能均有影响。
Objective To evaluate the effects of pulmonary hypertension (PAH) induced by systemic lupus erythematosus (SLE) on biventricular systolic function using real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking (2D- STI) Methods The subjects were divided into no NPAH, LPAH, MPAH, and severe PAH (SPAH) group according to the presence or absence of PAH, and each group had 23 cases, 19 cases, 18 cases and 12 cases. The left ventricular anterior wall (ANT), interventricular septum (SEP), lateral wall (LAT), and inferior myocardial (LV) longitudinal strain (LS) were calculated by 2D- ) Mean (LSA) and mean circumferential strain (CS) values were compared between groups. Results Only the LVEF of SPAH group dropped below the normal level; while LS decreased with the increase of PAH, the LSA of ANT and SEP decreased significantly, while the changes of INF and LAT did not change obviously; CS increased first and then decreased; SEP, ANT and INF CSA changes more obvious. Conclusions SLE-induced PAH has an effect on biventricular systolic function.