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随着活性氧(ROS)研究的深入,它在肿瘤细胞凋亡中的作用不断被肯定,目前临床上的许多传统化疗药物的抗肿瘤作用与ROS密切相关,并且许多正在临床或实验研究阶段的药物成分都是通过产生ROS而发挥抗肿瘤作用。肿瘤细胞对ROS的易感性及肿瘤细胞本身高浓度的ROS这两个因素,决定了在胞内同样浓度的ROS作用下,肿瘤细胞能够发生凋亡而正常细胞则耐受。白血病化疗药物如柔红霉素、长春新碱等抗肿瘤作用与ROS有关,抑制ROS的产生则化疗药物的活性受到抑制。
With the development of reactive oxygen species (ROS), its role in tumor cell apoptosis has been affirmed. At present, many antitumor effects of traditional chemotherapeutic drugs are closely related to ROS and many are in the clinical or experimental research stage Drug ingredients exert anti-tumor effects by generating ROS. Tumor cells to ROS susceptibility and high concentrations of tumor cells themselves ROS two factors that determine the same concentration of intracellular ROS, the tumor cells can apoptosis and normal cells are tolerated. Leukemia chemotherapy drugs such as daunorubicin, vincristine and other antitumor effects and ROS, inhibition of the production of ROS chemotherapy activity was inhibited.