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目的:分析川芎嗪注射液致药物不良反应(ADR)的一般规律及特点,为临床合理用药提供参考。方法:选取2013年1月—2014年12月间收治的川芎嗪所致ADR患者,以及同期文献报道的川芎嗪所致ADR患者32例,分析其所致ADR的规律与特点。结果:川芎嗪所致ADR以老年患者居多(50岁以上者有23例),用药过程中发生ADR者22例,其中ADR累及系统包括神经系统(4例)、皮肤及其附件(12例)、消化系统(2例)、心脑血管系统(10例)和生殖泌尿系统(4例)。结论:川芎嗪所致ADR存在一定的临床特点,在临床治疗用药过程中,应引起足够的重视,合理用药,以避免ADR的发生。
OBJECTIVE: To analyze the general rules and characteristics of drug-induced adverse reactions (ADR) caused by ligustrazine injection and to provide a reference for clinical rational drug use. Methods: ADR patients were selected from January 2013 to December 2014, and the ADR patients caused by ligustrazine in the same period were enrolled in the study. The regularity and characteristics of ADR were analyzed. Results: The incidence of ADR caused by ligustrazine was mostly in elderly patients (23 cases over the age of 50) and ADR occurred in 22 cases. ADR involved the nervous system (4 cases), skin and its appendages (12 cases) , Digestive system (2 cases), cardiovascular system (10 cases) and genitourinary system (4 cases). Conclusion: Tetramethylpyrazine induced ADR has certain clinical features. In the course of clinical treatment, enough attention should be paid to rational use of drug in order to avoid the occurrence of ADR.