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目的研究人乳腺癌组织中膜联蛋白A2(Annexin A2)的表达情况,阐明Annexin A2蛋白与乳腺癌发生发展的关系。方法运用蛋白质印迹(Western Blotting)和免疫组织化学技术检测人乳腺癌组织和癌旁组织中Annexin A2蛋白的表达情况,并分析Annexin A2与临床分期的关系。结果在相同上样量的情况下,Annexin A2在乳腺癌组织中表达明显高于癌旁组织。乳腺癌组织及癌旁组织中AnnexinA2蛋白的阳性表达率分别为89.47%(34/38)和42.10%(16/38),两者比较差异有统计学意义(P<0.05),其表达水平与TNM分期有关(P<0.05)。结论 Annexin A2蛋白的高表达可能与乳腺癌的发生、发展有关。
Objective To study the expression of annexin A2 in human breast cancer and to elucidate the relationship between Annexin A2 protein and the occurrence and development of breast cancer. Methods Western Blotting and immunohistochemistry were used to detect the expression of Annexin A2 protein in human breast cancer tissues and adjacent normal tissues. The relationship between Annexin A2 and clinical stage was analyzed. Results Annexin A2 was significantly higher in breast cancer tissues than in paracancerous tissues at the same loading level. The positive rates of Annexin A2 protein in breast cancer tissues and adjacent tissues were 89.47% (34/38) and 42.10% (16/38), respectively, with statistical significance (P <0.05) TNM staging (P <0.05). Conclusion The high expression of Annexin A2 protein may be related to the occurrence and development of breast cancer.