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目的:研究维库溴铵对老年病人的肌松效应。方法:94例病人(32-97岁)按年龄分为4组(A,B,C,D),A组为对照组B组60-69岁,C组70-89岁,D组90-97岁,均于全麻诱导时静注维库溴铵0．12 mg·kg-1,并进行神经肌肉阻滞监测。结果:(1)A组病人维库溴铵起效时间明显比其余3组长(P<0．01),D组病人肌松起效时间快于B组和C组(P<0．01)。(2)A组病人T1为零时间明显比其余3组病人长(P<0．01),B、C组T1为零时间无差异(P>0．05),D组病人则短于B组和C组(P<0．01)。(3)A组和B组首次给药后T110％恢复时间和停药后T125％恢复时间显著快于C组和D组(P<0．01)。(4)不同年龄组维库溴铵用量随年龄增加而减少(P<0．01)。结论:随着年龄的增长,高龄病人维库溴铵起效时间,达最大效能时间增快、维持用量减少和肌松持续时间延长。
Objective: To study the muscle relaxant effect of vecuronium on elderly patients. Methods: A total of 94 patients (32-97 years old) were divided into 4 groups (A, B, C and D) according to their age. Group A was control group B, 60-69 years old, C group 70-89 years old, 97 years old, intravenous vecuronium 0.12 mg · kg-1 at induction of general anesthesia, and neuromuscular block monitoring. Results: (1) The onset time of vecuronium in group A was significantly longer than that in the other three groups (P <0.01), and the onset time of muscle relaxant in group D was faster than those in groups B and C (P <0.01) ). (2) The T1 time of group A was significantly longer than that of the other three groups (P <0.01), while there was no difference between group B and group C (P> 0.05) Group and C group (P <0.01). (3) The recovery time of T110% and the recovery time of T125% after the first administration in group A and group B were significantly faster than those in group C and group D (P <0.01). (4) The amount of vecuronium in different age groups decreased with age (P <0.01). CONCLUSIONS: With age, the onset time of vecuronium in elderly patients, the maximal efficacy time, the decrease of maintenance dosage and the duration of muscle relaxant were prolonged.