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为了探索内皮素（ＥＴ）、肿瘤坏死因子（ＴＮＦ－α）在哮喘中的作用及相互关系。实验测定了哮喘豚鼠血以及肺泡灌洗液（ＢＡＬＦ）中的内皮素－１（ＥＴ－１）、ＴＮＦ－α的释放量，以及离体气道平滑肌细胞在ＴＮＦ－α刺激下对ＥＴ－１释放的影响。观察到ＥＴ－１、ＴＮＦ－α的含量在哮喘组明显高于对照组，同时，ＴＮＦ－α可刺激平滑肌细胞分泌ＥＴ－１。表明ＴＮＦ－α引起的ＥＴ－１释放对气道高反应性的形成和气道重建可能起一定的作用。
To explore the role and relationship of endothelin (ET) and tumor necrosis factor (TNF-α) in asthma. The levels of endothelin-1 (ET-1) and TNF-α in asthmatic guinea pig blood and bronchoalveolar lavage fluid (BALF) were measured in vitro, and the effects of TNF-α on ET-1 The impact of release. It was observed that ET-1 and TNF-α levels were significantly higher in the asthma group than in the control group, meanwhile, TNF-α stimulated the secretion of ET-1 by smooth muscle cells. It is suggested that the release of ET-1 by TNF-α may play an important role in the formation of airway hyperresponsiveness and airway remodeling.