目的 :观察颅内恶性肿瘤动脉超选择化疗的临床效果和预后。方法 :对 2 5例颅内恶性肿瘤采用超选择性脑动脉灌注替尼泊甙 (VM2 6 )和口服司莫司汀 ,化疗后半年行CT ,MRI检查测定肿瘤体积变化 ,评定临床疗效 ,Karnofsky评分评定预后。结果 :化疗后显效 10例 (4 0 % ) ,有效 8例 (32 % ) ,微效 3例 (12 % ) ,无效 2例 (8% ) ,恶化 1例 (4 % ) ,有效率 72 % ;Karnofsky评分 80分以上 13例 (5 2 % ) ,6 0～ 70分 8例 (32 % ) ,6 0分以下 4例 (16 % )。结论 :颅内恶性肿瘤采用动脉超选择化疗和口服司莫司汀胶囊治疗效果佳 ,安全性高 ,并发症少 ,全身反应轻 Objective: To observe the clinical effect and prognosis of intracranial malignant tumor with superselective chemotherapy. Methods: Twenty-five patients with intracranial malignant tumors were treated with intravenous infusion of teniposide (VM2 6) and oral simvastatin. The changes of tumor volume were measured by CT and MRI six months after the chemotherapy. Clinical efficacy was evaluated. Karnofsky Score to assess prognosis. Results: After chemotherapy, 10 cases (40%) were effective, 8 cases (32%) were effective, 3 cases (12%) were ineffective, 2 cases were ineffective (8%), 1 case was deteriorated (4% ; Karnofsky score more than 80 points in 13 cases (52%), 60 to 70 points in 8 cases (32%), 60 points in 4 cases (16%). Conclusion: Intracranial malignant tumors with arterial superselective chemotherapy and oral administration of Secretary Secretary capsule efficacy, high safety, fewer complications, less systemic reaction