急性呼吸功能不全是感染性休克的主要死因之一。本研究利用幼猪制备感染性休克实验动物模型,借助光镜和电镜观察感染性休克晚期肺的显微和超微结构,旨在从形态学方面探讨感染性休克引起急性呼吸哀竭的发病机理。实验方法:生后3～4周杂交家猪12头作为感染性休克实验动物,体重3.5～7.0 kg。采用末段回肠穿孔和腹腔注入致病性大肠杆菌[E.Coli O_(111):B_4,上海卫生防疫站 ATC(44536)]的方法制备腹膜炎、败血症和感染性休克的疾病模型。感染性休克诊断主要依据心输出量和平均动脉压变化。实验设 Acute respiratory insufficiency is one of the leading causes of septic shock. In this study, piglets were used to prepare experimental animal models of septic shock, and microscopic and ultrastructural changes of lungs in septic shock were observed by light and electron microscopy in order to explore the pathogenesis of acute respiratory distress caused by septic shock . Experimental methods: Twelve of the crossbreeding pigs 3 to 4 weeks after birth were used as experimental animals in septic shock weighing 3.5-7.0 kg. The peritonitis, sepsis and septic shock disease models were prepared using the distal ileal perforation and peritoneal injection of pathogenic E. coli [E. coli O_ (111): B_4, Shanghai Sanitation and Epidemic Station ATC (44536)]. Infectious shock diagnosis is mainly based on cardiac output and mean arterial pressure changes. Experimental set up