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本研究通过2000年至2002年,在乌鲁木齐七区一县15223名新婚妇女中从怀孕开始到孕后3个月末每日口服“斯利安片”(含0.4mg叶酸)的人群干预研究,评价小剂量叶酸增补剂对神经管畸形初发的预防作用。干预结果表明乌鲁木齐市的神经管畸形的发病率从服药前的32.52/10万下降至服药后的14.55/10万。这种经济简单、有效可行的增补叶酸预防神经管畸形的推广研究工作,可进一步在全疆范围内推广应用。为实现妇女儿童发展纲要、预防出生缺陷发生作出应有的贡献。
In this study, from 2000 to 2002, 15223 newlywed women in seven districts and one county of Urumqi were interviewed daily for the oral administration of “SiLian tablets” (containing 0.4 mg folic acid) from the beginning of pregnancy to the end of three months after pregnancy. Evaluation of preventive effect of small dose of folic acid supplement on neural tube defects. Intervention results showed that the incidence of neural tube defects in Urumqi decreased from 32.52 / 100000 before taking medicine to 14.55 / 100000 after taking medicine. This simple, effective and feasible addition of folic acid to prevent neural tube defects in the promotion of research work can be further promoted in the context of Xinjiang. In order to realize the outline for the development of women and children, make a due contribution to the prevention of birth defects.