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目的了解伴雷诺现象 (RP)的系统性红斑狼疮 (SLE)患者的临床特征。方法对近 4年在我院住院的 42例伴 RP的 SLE患者进行临床分析，并与 116例无 RP的 SLE患者进行对照。结果与无 RP组相比 ,有 RP组出现脱发、肌炎 /肌病、心脏受累和肺动脉高压的几率明显增高 (分别为 56.90％～ 83.33％， 9.48％～ 23.81％， 29.31％～ 59.52％， 1.72％～ 21.43％， P< 0.05或 0.01)。γ－球蛋白升高，抗核抗体、抗 RNP及抗 Sm抗体的阳性率也明显增高 (分别为 50.52％～ 73.68％ , 68.47％～ 87.80％ , 24.04％～ 70.00％ , 7.69％～ 35.00％ , P< 0.05或 0.01)。而两组患者在肾炎、神经系统受累及血液系统受累的发生率差异无显著性 (P均 >0.05)。对 125例患者进行了平均 2.15年的随访，其中包括全部的 11例肺动脉高压患者，死亡 3例，其中 1例死于肺动脉高压并发右心衰竭（有 RP组）。结论 SLE患者出现雷诺现象提示较易发生肺动脉高压、心脏受累和免疫学异常，对伴雷诺现象的 SLE患者应注意其心肺状态，以便早期诊断和治疗。
Objective To understand the clinical features of patients with systemic lupus erythematosus (SLE) with Raynaud’s phenomenon (RP). Methods 42 cases of SLE patients with RP who were hospitalized in our hospital for nearly 4 years were analyzed and compared with 116 cases of SLE without RP. Results Compared with no RP group, the incidence of hair loss, myositis / myopathy, heart involvement and pulmonary hypertension in RP group were significantly higher (56.90% -83.33%, 9.48% -23.81%, 29.31% -59.52% 1.72% ~ 21.43%, P <0.05 or 0.01). The positive rates of anti-nuclear antibody, anti-RNP and anti-Sm antibody were also significantly increased (50.52% -73.68%, 68.47% -87.80%, 24.04% -70.00%, 7.69% -35.00% P <0.05 or 0.01). There was no significant difference in the incidence of nephritis, nervous system involvement and blood system involvement between the two groups (all P> 0.05). A total of 125 patients were followed up for an average of 2.15 years, including all 11 patients with pulmonary hypertension and 3 deaths, 1 of which died of pulmonary hypertension with right ventricular failure (RP group). Conclusion Reynolds phenomenon in patients with SLE is more likely to occur pulmonary hypertension, cardiac involvement and immunological abnormalities, and SLE patients with Raynaud’s phenomenon should pay attention to their cardiorespiratory status for early diagnosis and treatment.