目的分析中国处于三个不同地理环境地区的母体成熟乳中脂肪酸含量的差异。方法选取江苏句容(河湖地区)、山东日照(沿海地区)和河北徐水(内陆地区)三地,每地区募集40～50名健康产妇,于产后第28天采集母乳,Folch法提取其中脂肪,气相色谱法分析其中31种脂肪酸构成及含量。结果句容,日照和徐水分别募集到47、50和46名受试者,各地成熟乳中饱和脂肪酸(SFA)、单不饱和脂肪酸(MUFA)、n-6多不饱和脂肪酸(n-6PUFA)和n-3多不饱和脂肪酸(n-3PUFA)的主要成份均分别为C16∶0、C18∶1 n-9cis、C18∶2 n-6 cis和C18∶3 n-3。三地区成熟乳中花生四烯酸(ARA)百分含量中位数分别为0.72%、0.63%和0.63%;二十二碳六烯酸(DHA)分别为0.41%、0.47%和0.24%。三地区总乳脂含量中位数分别为4.47、1.50和3.91g/100g母乳;其总脂肪酸含量中位数分别为3934、1319和3437mg/100g母乳,日照总乳脂含量和总脂肪酸含量显著低于另两地区。结论母体成熟乳中脂肪酸含量及构成存在显著地区差异性。 Objective To analyze the differences in fatty acid content of maternal mature milk in three different geographic regions in China. Methods Thirty healthy maternal mothers were recruited in each district from jurong (river and lake area) in jiangsu, sunshine in Shandong (coastal area) and xushui (inland area) in Hebei province. Breast milk was collected on the 28th day postpartum. Folch extraction Among them, 31 kinds of fatty acids were analyzed by fat and gas chromatography. Results Jurong, Rizhao and Xuhui recruited 47, 50 and 46 subjects respectively. The content of SFA, MUFA, n-6 PUFA ) And n-3 polyunsaturated fatty acids (n-3 PUFA) are C16: 0, C18: 1 n-9 cis, C18: 2 n-6 cis and C18: 3 n-3, respectively. The median percentage of arachidonic acid (ARA) in mature milk in three regions was 0.72%, 0.63% and 0.63%, respectively. DHA was 0.41%, 0.47% and 0.24%, respectively. The median total fat content of the three regions were 4.47,1.50 and 3.91g / 100g breast milk respectively; the median total fatty acid content was 3934, 1319 and 3437mg / 100g breast milk respectively, the suger total fat content and total fatty acid content were significantly lower than the other Two regions. Conclusion There are significant regional differences in the content and composition of fatty acids in the mature milk of maternal.