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目的:探讨系统性红斑狼疮(SLE)患者血清中的IL-17、IL-6水平及其与疾病活动性之间的相关性。方法:选取40例SLE患者和40例正常对照者,采用ELISA法测试其血清IL-17和IL-6,仪器法检测ESR,免疫比浊法检测血清C_3、C_4、IgG、IgA、IgM。结果:SLE患者组的血清补体C_3、C_4、IgG、IgM、IL-17、IL-6水平与正常对照组比较差异有统计学意义;患者组血清补体C_3水平与疾病活动指数(SLEDAI)呈负相关,IL-17、IL-6水平与SLEDAI呈正相关。同时发现IL-17与IL-6之间、IL-17/IL-6与SLEDAI之间也分别存在相关性。结论:IL-17、IL-6可能在SLE的发生和发展过程中起到较为重要的作用。
Objective: To investigate the serum levels of IL-17 and IL-6 in patients with systemic lupus erythematosus (SLE) and its correlation with disease activity. Methods: Forty patients with SLE and 40 normal controls were enrolled. Serum IL-17 and IL-6 levels were measured by ELISA. Serum C_3, C_4, IgG, IgA and IgM were detected by turbidimetry. Results: The levels of serum complement C_3, C_4, IgG, IgM, IL-17 and IL-6 in patients with SLE were significantly different from those in normal controls. The levels of serum complement C_3 and SLEDAI in patients with SLE were negative Correlation, IL-17, IL-6 levels and SLEDAI was positively correlated. The correlation between IL-17 and IL-6, IL-17 / IL-6 and SLEDAI was also found. Conclusion: IL-17 and IL-6 may play important roles in the development and progression of SLE.