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目的提高对恶性淋巴瘤合并肺部病变的认识和诊疗水平。方法报告 1例合并多器官侵犯的非霍奇金淋巴瘤 ,其外周血、骨髓及淋巴结、皮肤标本分别采用光镜、免疫组化染色和胸部CT研究肿瘤细胞的特征。结果本例患者肿瘤为B淋巴细胞来源 ,表达CD 2 0、CD 45RA ,肿瘤细胞胸部浸润表现双肺弥漫性云雾状分布 ,磨玻璃状密度增高影 ,纵隔内淋巴结肿大。化疗效果差。结论恶性淋巴瘤出现肺间质浸润少见 ,应予重视
Objective To improve the understanding and diagnosis of malignant lymphoma with pulmonary lesions. Methods One non-Hodgkin lymphoma with multi-organ invasion was reported. The peripheral blood, bone marrow, lymph nodes and skin specimens were examined by light microscopy, immunohistochemistry and chest CT respectively. Results The tumor of this patient was the source of B lymphocytes, which expressed CD20, CD45RA. The diffuse cloudiness distribution of lungs in the chest of infiltrating tumor cells, the increase of ground glassy density and the enlargement of mediastinal lymph nodes. Chemotherapy is poor. Conclusions Malignant lymphoma is rare in pulmonary interstitial infiltration and should be paid attention to