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目的:了解抗感染药物相关药源性肾损伤的发生情况及特点,为临床用药提供参考。方法:调取2009~2013年解放军不良反应监测中心数据库中抗感染药物相关的药源性肾损伤报告209例,对涉及的患者年龄、性别、药源性肾损伤的药物类别、品种、给药途径、发生时间、实验室指标、临床表现及转归等情况进行描述性统计分析。结果:209例药源性肾损伤中,男149例(71.29%),女60例(28.71%),平均年龄(53.48±23.62)岁。涉及抗感染药品5大类54个品种,引起ADR频次前3位的药物分别为克林霉素、万古霉素、左氧氟沙星。静脉滴注是引起ADR的主要给药途径,占87.08%。ADR的发生时间相对集中,多在用药后1周以内(84.21%)。对可进行肾损伤分期的108例ADR评价,2、3期患者共56例,占51.85%。大部分病例预后良好,其中治愈和好转共185例(88.52%)。结论:抗感染药物相关肾损伤涉及的药物种类和品种较多,且多发生在1周以内,临床应提高对抗感染药物相关肾损伤的认识,并重点关注引发药源性肾损伤频次较高的抗感染药物。
Objective: To understand the occurrence and characteristics of drug-induced renal injury associated with anti-infectives and provide reference for clinical use. METHODS: 209 cases of drug-induced renal injury associated with anti-infectives were retrieved from the People’s Liberation Army’s Adverse Reaction Monitoring Center database from 2009 to 2013. The types, types and types of drugs involved in the patient’s age, gender, drug-induced renal injury Route, time of occurrence, laboratory indicators, clinical manifestations and outcome of the descriptive statistical analysis. Results: Of the 209 drug-induced renal injuries, 149 were male (71.29%) and 60 were female (28.71%), with an average age of 53.48 ± 23.62 years. Involved in anti-infective drugs 5 categories 54 species, causing the first three ADR frequency drugs were clindamycin, vancomycin, levofloxacin. Intravenous drip is the main route leading to ADR, accounting for 87.08%. ADR occurred relatively concentrated time, mostly within 1 week after medication (84.21%). A total of 108 ADR patients with staging of renal injury were evaluated, and 56 patients (stage 2 and stage 3) accounted for 51.85%. In most cases, the prognosis was good, of which 185 cases were cured and improved (88.52%). CONCLUSIONS: Anti-infective drug-related renal injury involves more types and varieties of drugs and occurs frequently within one week. Clinical knowledge of anti-infective drug-related renal injury should be increased and the frequency of drug-induced renal injury should be emphasized Anti-infectives.