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目的:了解武汉市2012年手足口病的病原学情况,为本地区手足口病的防治提供依据。方法:用实时荧光定量RT-PCR方法检测患者咽拭子中肠道病毒71型(EV71)和柯萨奇病毒A组16型(CA16)核酸。结果:332例患者中,EV71核酸阳性110例,阳性率33.1%;其中83例患者进行了CA16检测,阳性率20.5%;EV71和CA16双阳性2例,阳性率2.4%;手足口病男性患儿人数明显高于女性(P<0.05)。结论:武汉市儿童手足口病主要是感染EV71,同时伴有CA16的流行。
Objective: To understand the etiology of hand-foot-mouth disease in Wuhan in 2012 and provide the basis for prevention and treatment of hand-foot-mouth disease in this area. Methods: Real-time fluorescent quantitative RT-PCR was used to detect the pharyngeal swab enterovirus 71 (EV71) and Coxsackie virus A group 16 (CA16). Results: Of the 332 patients, 110 were positive for EV71 nucleic acid, with a positive rate of 33.1%. 83 of them were detected by CA16, the positive rate was 20.5%. The positive rate of EV71 and CA16 was 2%, and the positive rate was 2.4% The number of children was significantly higher than that of women (P <0.05). Conclusion: Hand, foot and mouth disease of children in Wuhan is mainly infected with EV71, accompanied by the prevalence of CA16.