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引起乙型肝炎病毒(hepatitis B virus,HBV)感染后慢性化的因素有宿主因素和病毒因素。宿主因素主要有免疫功能、细胞凋亡蛋白抑制因子(cellular inhibitor of apoptosis proteins,c IAPs)以及HLA基因多态性等使宿主不能产生有效的抗病毒反应;病毒因素主要包括乙肝病毒基因型、乙肝病毒变异、乙肝病毒抗原等,导致HBV持续存在肝细胞中不能被清除。本文综合最新国内外进展对乙肝病毒感染后慢性化的发生机制进行综述。
Factors that cause chronicity after infection with hepatitis B virus (HBV) include host and viral factors. The main host factors are immune function, cellular inhibitor of apoptosis proteins (c IAPs) and HLA gene polymorphisms so that the host can not produce effective antiviral response; viral factors include hepatitis B virus genotypes, hepatitis B Virus mutation, hepatitis B virus antigen, leading to the persistence of HBV can not be cleared in liver cells. This review summarizes the mechanism of chronicity after hepatitis B virus infection based on the latest progress at home and abroad.