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目的观察分析糖尿病性心肌病(DCM)患者血清C-反应蛋白(CRP)和白细胞介素-37(IL-37)的水平,探讨CRP和IL-37与DCM发病的关系。方法对深圳市宝安区人民医院2009年9月至2013年2月收治的24例确诊DCM患者及同期的健康体检者22人进行空腹血糖、血胆固醇(TC)、血甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDL-C)、血尿素氮(BUN)、血肌酐(Cr)等生化指标检测,同时采用免疫透射比浊法测定血清CRP含量,ELISA法检测血清IL-37水平,对比分析两组血清CRP和IL-37水平与DCM患病的相关性。结果 DCM组CRP含量为(6.9±1.4)mg/dl,对照组为(1.9±0.4)mg/dl,差异有统计学意义(P<0.05);CRP含量与血清HDL-C水平呈负相关(r=-0.938,P<0.05),而与LDL-C水平呈正相关(r=0.665,P<0.05)。DCM组IL-37含量为(12.2±8.9)pg/ml,对照组为(2.8±4.5)pg/ml,差异有统计学意义(P<0.05);IL-37含量与HDL-C水平呈负相关(r=-0.765,P<0.05),而与LDL-C水平呈正相关(r=0.894,P<0.05)。结论 DCM患者血清CRP和IL-37水平明显升高,且均与HDL-C水平呈负相关,与LDL-C水平呈正相关,提示炎症与DCM的发病和发展密切相关。
Objective To observe the levels of serum C-reactive protein (CRP) and interleukin-37 (IL-37) in patients with diabetic cardiomyopathy (DCM) and to explore the relationship between CRP, IL-37 and DCM. Methods Twenty-four patients diagnosed with DCM and 22 healthy people in Baoan District People’s Hospital of Shenzhen City from September 2009 to February 2013 were enrolled in this study. Fasting blood glucose (TC), blood cholesterol (TC), triglyceride (TG) HDLC, LDL-C, BUN and Cr were detected by enzyme-linked immunosorbent assay (ELISA). Serum CRP levels were determined by immunoturbidimetry and ELISA Method to detect serum IL-37 levels, comparative analysis of serum CRP and IL-37 levels and DCM correlation between the prevalence. Results The CRP level in DCM group was (6.9 ± 1.4) mg / dl and that in control group was (1.9 ± 0.4) mg / dl, the difference was statistically significant (P <0.05); CRP level was negatively correlated with serum HDL- r = -0.938, P <0.05), but positively correlated with LDL-C (r = 0.665, P <0.05). The level of IL-37 in DCM group was (12.2 ± 8.9) pg / ml and that of control group was (2.8 ± 4.5) pg / ml, the difference was statistically significant (R = -0.765, P <0.05), but positively correlated with LDL-C level (r = 0.894, P <0.05). Conclusion Serum levels of CRP and IL-37 in patients with DCM are significantly increased, and are negatively correlated with HDL-C levels and positively correlated with LDL-C levels, suggesting that inflammation is closely related to the pathogenesis and development of DCM.