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基质细胞衍生因子1α(stromal derived factor 1α,SDF-1α)和其受体CXCR4构成的SDF-1α/ CXCR4轴在调节干/祖细胞“归巢”受损心肌中起关键作用。深入研究此轴的启动和调控机制,对干/祖细胞治疗缺血性心脏病有重要意义。
The SDF-1α / CXCR4 axis composed of stromal derived factor 1α (SDF-1α) and its receptor CXCR4 plays a key role in the regulation of damaged myocardium in stem / progenitor cells. In-depth study of this axis of the start-up and regulation mechanism of stem / progenitor cells for the treatment of ischemic heart disease is of great significance.