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目的:探讨加减镇肝熄风汤联合西药治疗急性期糖尿病性脑梗死临床疗效分析及不良反应观察。方法:选择2012年5月—2013年10月期间在医院接受诊治的急性期糖尿病脑梗死患者77例。根据随机数字表法将其分为对照组(n=37)与治疗组(n=40)。两组均给予糖尿病常规治疗。对照组治疗采用依拉达奉注射液;治疗组在依拉达奉注射液治疗基础上采用镇肝熄风汤加减治疗,组成包括怀牛膝、生赭石、生龙骨、生牡蛎、生龟板、生杭芍、玄参、天冬、川楝子、生麦芽、茵陈、甘草。两组患者均以14 d为1个疗程,1个疗程后观察疗效及不良反应。两组患者一般资料之间对比分析表明无显著性差异(P>0.05)。结果:治疗组总有效率(92.50%)显著高于对照组(78.37%),且有显著性差异(P<0.05);治疗组治疗后神经功能缺损程度评分(7.94±4.25)显著低于对照组(12.03±5.36),且有显著性差异(P<0.05);治疗组治疗后ADL评分显著高于对照组,且有显著性差异(P<0.05);治疗组治疗后血浆黏度、APTT与对照组治疗后比较有显著性差异(P<0.05);两组患者在治疗期间均无明显不良反应发生。结论:针对急性期糖尿病性脑梗死患者采用加减镇肝熄风汤结合西药进行治疗效果明显,能够改善患者血液流变学,改善患者神经功能缺损且无明显不良反应,具有重要研究意义。
Objective: To investigate the clinical efficacy and adverse reactions of plus and minus Zhengan Xifeng Decoction combined with Western medicine in the treatment of acute cerebral infarction. Methods: A total of 77 patients with acute cerebral infarction in our hospital from May 2012 to October 2013 were selected. According to the random number table, they were divided into control group (n = 37) and treatment group (n = 40). Both groups were given routine treatment of diabetes. The control group was treated with Elada Feng injection. The treatment group was treated with Zhengan Xifeng Decoction based on the treatment of Elada Beng injection. The treatment group included Achyranthes bidentata, raw ocher, raw keel, raw oyster, Health Hang Shao, Scrophulariaceae, Asparagus, Toosendan, raw malt, capillaris, licorice. Two groups of patients were 14 days for a course of treatment, after a course of treatment to observe the efficacy and adverse reactions. The comparative analysis between the two groups of patients showed no significant difference (P> 0.05). Results: The total effective rate (92.50%) in the treatment group was significantly higher than that in the control group (78.37%), and there was a significant difference (P <0.05). The score of neurological deficit in the treatment group (7.94 ± 4.25) (12.03 ± 5.36), and there was significant difference (P <0.05). After treatment, the ADL score of the treatment group was significantly higher than that of the control group (P <0.05). After treatment, the plasma viscosity, APTT, There was a significant difference in the control group after treatment (P <0.05); no adverse reactions occurred in both groups during the treatment. Conclusion: The treatment of patients with acute phase of cerebral infarction with Addition and subtraction Zhengan Xifeng Decoction combined with western medicine has obvious curative effect, which can improve hemorheology, improve neurological deficits and have no obvious adverse reactions in patients with acute cerebral infarction. It is of great significance.