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儿童支气管哮喘(bronchial asthma,BA)是一多基因遗传的免疫性疾病,根据症状严重程度分为间歇、轻、中、重度发作。HLA在不同种族、民族和地区间分布不同。我们用PCR-SSO技术,研究内蒙地区汉族儿童BA间歇和重度发作与HLA-DRB1等位基因的关联性,旨在探讨其发病机理和防治前景。
Children bronchial asthma (BA) is a polygenic inherited immune disease, divided into intermittent, mild, moderate and severe seizures according to the severity of the symptoms. HLA is distributed differently between races, nations and regions. We used PCR-SSO technology to study the association between intermittent and severe seizures of BA and HLA-DRB1 alleles in Han children in Inner Mongolia to explore the pathogenesis and prevention and treatment of BA.