论文部分内容阅读
目的分析MRI和1H-MRS对线粒体脑肌病的诊断价值。方法经病理活检确诊的6例成人(男3例,女3例)线粒体脑肌病患者采用1.5T磁共振仪扫描,其中3例行1H-MRS检查,并分析MRI和1H-MRS的表现。结果6例线粒体脑肌病患者MRI显示病变累及多个脑叶,多位于皮层及皮层下白质,并可同时累及大脑深部灰质和大脑皮层。脑梗死样病灶呈斑片状或楔形,非对称性。T1WI为低信号或等低信号,T2WI为高信号。急性期病变区域脑组织轻度肿胀,慢性期全脑萎缩,并可见皮质层状坏死。4例行MR增强扫描未见强化。3例1H-MRS检查均显示病灶内Lac峰明显升高和NAA峰不同程度的降低。结论线粒体脑肌病MRI表现具有一定的特征,1H-MRS可提供更多脑组织代谢信息,对本病诊断具有重要的价值。
Objective To analyze the diagnostic value of MRI and 1H-MRS in mitochondrial encephalomyopathy. Methods Six patients (3 males and 3 females) with mitochondrial encephalomyopathy diagnosed by pathological biopsy were scanned by 1.5T magnetic resonance scanner. Three cases were examined by 1H-MRS, and MRI and 1H-MRS were analyzed. Results MRI of 6 patients with mitochondrial encephalomyopathy showed that the lesion involved multiple brain lobes, mostly in the cortex and subcortical white matter, and could simultaneously affect the deep gray matter and cerebral cortex of the brain. Cerebral infarction-like lesions were patchy or wedge-shaped, asymmetric. T1WI is low signal or low signal, T2WI is high signal. Acute lesions of brain tissue mild swelling, chronic atrophy of the brain, and cortical necrosis seen. 4 routine MR enhanced scan no enhancement. 1H-MRS examination in 3 cases showed that the Lac peak in the lesion was significantly increased and the NAA peak was decreased to some extent. Conclusion The MRI findings of mitochondrial encephalomyopathy have certain characteristics. 1H-MRS can provide more information on metabolism of brain tissue, which is of great value to the diagnosis of this disease.