目的　建立实用而与爆炸性武器致伤机制接近的犬颅脑爆炸伤模型。　方法　 2 0只犬随机分为对照组 (8只 )和致伤组 (12只 )。用高速钢球模拟爆炸性武器的爆炸破片 ,以同步电雷管爆炸所产生的爆轰波模拟爆炸性武器的爆炸冲击波 ,建立颅脑爆炸伤模型。记录致伤前后生理指标的变化 ,观察其组织病理学改变。　结果　动物伤后均出现呼吸暂停、心率减慢、平均动脉压降低等脑干抑制现象 ;脑电活动消失 ,脑电图呈一直线 ;颅内压呈明显的瞬时增高后下降 ,再进行性增高的特征性改变 ;挫伤区与震荡区边界不清 ,硬膜下血肿和蛛网膜下腔出血较为明显 ,全脑有点状出血。　结论　 (1)该模型的伤情与实际爆炸伤接近 ,重复性和稳定性好 ,安全而易操作 ,能在实验室内进行 ;(2 )呼吸抑制是颅脑爆炸伤动物早期死亡的主要原因 ,积极有效的辅助呼吸能减少颅脑爆炸伤动物的死亡率 ;(3)颅内高压出现早且明显 ;(4 )挫伤区与震荡区边界不清 ,颅内血肿发生率高。 Objective To establish a practical model of explosive brain injury caused by blast injury in dogs. Methods Twenty dogs were randomly divided into control group (n = 8) and injury group (n = 12). High-speed steel balls were used to simulate the explosive fragments of explosive weapons. The detonation waves generated by explosive detonators were simulated to simulate the explosive shock wave of explosive weapons and the model of brain explosion injury was established. Changes in physiological indicators before and after injury were recorded and histopathological changes were observed. Results After the animals were injured, apnea, slow heart rate, mean arterial pressure and other inhibition of brainstem; EEG disappeared, EEG showed a straight line; intracranial pressure was significantly increased immediately after the decline, and then increased Of the characteristic changes; bruises and concussion area border is unclear, subdural hematoma and subarachnoid hemorrhage is more obvious, a little bit of the whole brain hemorrhage. Conclusions (1) The injury of this model is close to the actual blast injury, the repeatability and stability are good, safe and easy to operate, and can be carried out in the laboratory. (2) Respiratory depression is the main reason of early death of animals injured by brain explosion , Active and effective assisted breathing can reduce the mortality rate of brain explosive blast injury animals; (3) appeared early and obvious intracranial hypertension; (4) bruises and concussion area border is unclear, high incidence of intracranial hematoma.