目的 :研究妊娠期单纯低T4血症对孕妇妊娠结局及胎儿的影响。方法 :256例妊娠期单纯低T4血症孕妇为低T4血症干预组,134例妊娠期单纯低T4血症孕妇为低T4血症未干预组,并以158例甲状腺激素检测正常孕妇为对照组,比较三组孕妇妊娠结局以及新生儿情况。结果 :三组妊娠糖尿病及胎儿窘迫发生率存在统计学差异,低T4血症未干预组妊娠糖尿病(23.88%)及胎儿窘迫发生率(20.90%)高于低T4血症干预组及对照组,低T4血症干预组及对照组妊娠糖尿病及胎儿窘迫发生率无统计学差异;三组妊娠高血压疾病、胎盘早剥、早产儿、低体重儿发生率无统计学差异;不同时间干预低T4血症患者妊娠并发症的发生情况及新生儿情况比较,妊娠早期妊娠糖尿病(0)及胎儿窘迫发生率(0)低于妊娠中期、妊娠晚期;三组妊娠高血压疾病、胎盘早剥、早产儿、低体重儿发生率无统计学差异。结论 :低水平T4与妊娠糖尿病及胎儿窘迫妊娠并发症的发生密切相关,在妊娠早期对单纯低T4血症进行干预对预防妊娠糖尿病及胎儿窘迫的发生有良好的临床价值。 Objective: To study the effect of simple hypo-T4 hyperlipidemia on pregnancy outcome and fetus in pregnant women. Methods: A total of 256 pregnant women with low T4 plasma during pregnancy were included in the intervention group, and 134 pregnant women with hypomagnesemia in gestational age were treated with T4 hypomagnesemia. 158 pregnant women with thyroid hormone as control Group, comparing the pregnancy outcome of three groups of pregnant women and neonatal conditions. Results: The incidence of gestational diabetes mellitus and fetal distress in the three groups were statistically different. The gestational diabetes mellitus (23.88%) and the incidence of fetal distress (20.90%) in the low intervention group were higher than those in the low T4 intervention group and the control group There was no significant difference in the incidence of gestational diabetes mellitus and fetal distress between the intervention group and the control group. The incidence of pregnancy-induced hypertension, placental abruption, premature infant and low birth weight infants in the three groups had no statistical difference. The incidence of pregnancy complications in patients with blood disease and newborns, gestational diabetes in early pregnancy (0) and fetal distress (0) was lower than in the second trimester of pregnancy, third trimester of pregnancy-induced hypertension, placental abruption, premature labor Children, low birth weight children no significant difference. Conclusion: Low level of T4 is closely related to the occurrence of gestational diabetes mellitus and fetal distress pregnancy complications. Intervention in the first trimester of pregnancy with low hypo - T4mia has good clinical value in preventing gestational diabetes mellitus and fetal distress.