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肿瘤的生长与迁移离不开新血管的形成,这使得抗血管新生成为肿瘤治疗的重要途径之一。血管内皮生长因子(VEGF)是针对内皮细胞作用最强、特异性最高的血管新生促进因子,因而VEGF是抗肿瘤治疗的重要靶点。我们简要介绍了VEGF的一些生物学特点及肿瘤血管新生,着重介绍了一些抗血管新生药物的最新研究成果及其临床应用。
Tumor growth and migration can not be separated from the formation of new blood vessels, which makes anti-angiogenesis as one of the important ways of cancer treatment. Vascular endothelial growth factor (VEGF) is the most potent and specific angiogenesis promoting factor for endothelial cells, therefore, VEGF is an important target of anti-tumor therapy. We briefly introduced some of the biological characteristics of VEGF and tumor angiogenesis, highlighting some of the latest research results of anti-angiogenic drugs and its clinical application.