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大量的研究证明,实体瘤的生长和转移有赖于新生血管形成.血管内皮生长因子是一个重要的血管形成因子.有文献报道,胃癌、脑肿瘤的新生血管化程度与肿瘤侵袭性及其预后有相关性,是一个独立的预后因素.对术后确诊为原发性肝癌的患者进行长期预后的随访结果很令人失望,这些患者的术后肝内复发率很高.肿瘤的大小、门脉的侵袭和肝内转移被认为是导致复发的主要因素.我们采用免疫组织化学方法检测血管内皮生长因子及Ⅷ因子在原发性肝癌中的表达,同时采用 TUNEL 法测定肿瘤细胞的凋亡指数,以探讨血管内皮生长因子与原发性肝癌的肿瘤生物学行为及凋亡指数的相关性.
A large number of studies have demonstrated that the growth and metastasis of solid tumors depend on the formation of new blood vessels. Vascular endothelial growth factor is an important angiogenic factor. It has been reported in the literature that the degree of neovascularization and tumor invasiveness and prognosis of gastric cancer and brain tumors Relevance is an independent prognostic factor. The long-term prognosis of patients diagnosed with primary liver cancer after surgery is very disappointing. The postoperative intrahepatic recurrence rate is high. The size of the tumor, the portal vein Invasion and intrahepatic metastasis are considered to be the main factors leading to recurrence. We used immunohistochemistry to detect the expression of vascular endothelial growth factor and factor VIII in primary liver cancer, and the TUNEL method was used to determine the apoptosis index of tumor cells. To explore the correlation between vascular endothelial growth factor and tumor biological behavior and apoptosis index of primary liver cancer.