人参中的三醇皂苷对乙酰胆碱(ACh)引起的牛肾上腺髓质细胞释放儿茶酚胺(CA)有强的抑制作用,二醇系皂苷该作用较弱。人参皂苷在消化道被代谢后,不仅三醇系,二醇系也有强的抑制CA释放的作用,其作用机制是通过烟碱性ACh受体阻滞Na+内流。这些代谢物的生物活性,反映了人参的部分药 Trisaponin in ginseng has a strong inhibitory effect on the release of catecholamine (CA) from bovine adrenal medulla cells caused by acetylcholine (ACh), and the effect of diol saponins is weak. After ginsenosides are metabolized in the digestive tract, not only the triols but also the glycols have a strong inhibitory effect on the release of CA. The mechanism of action is that the Na+ influx is blocked by the nicotinic ACh receptor. The biological activity of these metabolites reflects some of the ginseng drugs