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采用免疫组织化学法检测survivin、bcl- 2蛋白在8例正常垂体组织及38例垂体腺瘤组织中的表达。结果提示survivin蛋白的表达阳性率与垂体腺瘤组织中的bcl -2蛋白表达密切相关,survivin蛋白表达异常引起的细胞凋亡抑制在垂体腺瘤的发生中起一定作用。
Immunohistochemistry was used to detect the expression of survivin and bcl-2 protein in 8 cases of normal pituitary tissue and 38 cases of pituitary adenoma. The results suggest that the positive expression rate of survivin protein is closely related to the expression of bcl-2 protein in pituitary adenomas. The inhibition of apoptosis induced by abnormal expression of survivin may play a role in the development of pituitary adenomas.