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目的 探讨血清甲胎蛋白 (AFP)、α L 岩藻糖苷酶 (AFU )、r 谷氨酰转肽酶 (GGT )、血清糖抗原 19 9(CA19 9)对原发性肝癌的诊断价值。方法 对 5 9例原发性肝癌 (PHC)、47例良性肝病及 41名正常人进行AFP、AFU、GGT、CA19 9的同步测定和对照。结果 AFP、AFU、GGT、CA19 9对PHC诊断的敏感性依次为 76 .3 %、84.7%、6 6 .1%、和 6 7.8% ,特异性为 85 .2 %、88.6 %、5 6 .8%、和 80 .6 %。联合检测对PHC诊断的敏感性可提高为 94.9%。结论 多种肿瘤标志物联合检测对诊断PHC具有重要价值
Objective To investigate the diagnostic value of serum alpha fetoprotein (AFP), α L fucosidase (AFU), r glutamyl transpeptidase (GGT) and serum carbohydrate antigen 19 9 (CA19 9) in primary liver cancer. Methods Simultaneous determination and comparison of AFP, AFU, GGT and CA19 9 were performed in 59 primary liver cancer (PHC), 47 benign liver disease and 41 healthy persons. Results The sensitivities of AFP, AFU, GGT, and CA19 9 to PHC diagnosis were 76. 3%, 84.7%, 6 6.1 %, and 6 7.8% respectively, and the specificity was 85.2%, 88.6 %, 5 6 . 8%, and 80.6%. Combined detection of PHC diagnosis sensitivity can be increased to 94.9%. Conclusion Combined detection of multiple tumor markers is of great value in diagnosing PHC