正常妇女绝经后 ,冠心病 (CHD)的发病率与绝经前相比呈显著增加。且其病程经过和治疗效果、预后等亦远逊于同龄男性。因此 ,认为女性激素衰退、减少与妇女 CHD的发病和发展密切相关。自80年代后期至今已有不少有关雌激素替代治疗(下称替代治疗 )的多中心 ,大宗病例的临床研究 , The incidence of coronary heart disease (CHD) in normal women after menopause was significantly higher than that before menopause. And its duration and treatment, prognosis is also far less than the same age men. Therefore, the female hormone decline, reduction and women’s CHD is closely related to the incidence and development. Since the late 1980s, there have been many clinical studies on multicenter and bulk cases of estrogen replacement therapy (hereinafter referred to as replacement therapy)